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View full-text article in PMC

. 2021 Sep 30;297(5):101267. doi: 10.1016/j.jbc.2021.101267

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Conformational profiles and levels of amyloid beta (Aβ42) in the frontal, occipital, and temporal neocortex of Alzheimer's disease (AD) patients and non-AD controls. Concentration (left panels) and conformational profile (right panels) of Aβ42 in (A and B) frontal cortex, (C and D) occipital cortex, and (E and F) temporal cortex of rapidly progressive AD (rpAD) (red) and slowly progressive AD (spAD) (blue) cases were investigated. The data were obtained with alphaLISA-formatted conformation-dependent immunoassay before (native, N) and after complete denaturation with guanidine hydrochloride (denatured, D) (17). The concentrations are expressed in nanograms per milliliter of 10% brain homogenate, and different D/N ratios indicate the presence of varying Aβ42 conformations. Each data point here represents an average of two measurements for the given anatomical region of each individual case. The statistical significance was determined with two-way ANOVA. NS, not significant; OND (green), other neurodegenerative diseases.