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. 2021 Oct 14;2021:9318725. doi: 10.1155/2021/9318725

Table 1.

Immunosuppressants, their mode of action and immunological outcomes in COVID-19.

Immunosuppressant class Examples Mode of action Immunological outcomes in COVID-19 Reference
Corticosteroids Dexamethasone, prednisone Inhibition of lymphocyte gene expression Suppressing cytokine storm prohibition of proinflammatory cytokine production, preserving the permeability and integrity of endothelium [74]
Antimetabolites Mycophenolic acid, azathioprine Blocking DNA replication Diminished immune response in vitro [75]
Calcinurine inhibitors Cyclosporine, tacrolimus Inhibition of lymphocyte signalling Selective inhibition of cytokine production and function [57]
mTOR inhibitors Sirolimus, everolimus Inhibition of mammalian target of rapamycin (mTOR) Inducing and cell cycle arrest in lymphocytes [76]
Biologics IL-2 inhibitors (daclizumab), IL-6 inhibitors(tocilizumab) Act as anticytokine antibodies Inhibiting the production of cytokines and thus alleviation of cytokine storm [77]