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. 2021 Oct 8;12:745893. doi: 10.3389/fimmu.2021.745893

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Copyright © 2021 Najem, Marisetty, Horbinski, Long, Huse, Glitza Oliva, Ferguson, Kumthekar, Wainwright, Chen, Lesniak, Burks and Heimberger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Representative images of different cell populations seen in the TME of melanoma LMD: pSTAT3-CD3+ T cells, pSTAT3+CD68+ macrophages, pSTAT3-CD11c+ APCs, pSTAT3+CD163+ macrophages, pSTAT3-CD11c+CD163+ APCs, and tumor cells demonstrating heterogenous nuclear expression of pSTAT3. (B) Dot-plot representing the percentages of total immune cells in the tumor area vs stroma. The black circles represent the total immune cell populations in the tumor and the black-outlined triangles represent the total immune cells in the stroma. Each circle or triangle represent a specimen. There is a significant difference between the percentages of CD3+ T cells in the stroma vs in the tumor (p= 0.039). (C) Dot-plot representing percentages of pSTAT3+ immune cells in the tumor area vs stroma. The green circles represent pSTAT3+ immune cell populations in the tumor area and the green-outlined triangles represent pSTAT3+ immune cells in the stroma. Each circle or triangle represent a specimen.