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. 2021 Oct 8;12:745893. doi: 10.3389/fimmu.2021.745893

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Copyright © 2021 Najem, Marisetty, Horbinski, Long, Huse, Glitza Oliva, Ferguson, Kumthekar, Wainwright, Chen, Lesniak, Burks and Heimberger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Dot plot showing % of pSTAT3- vs pSTAT3+ cells in the tumor area. Green circles represent pSTAT3+ populations and black circles represent pSTAT3- populations. Each circle represents a specimen. Red-outlined rectangles highlight the significative comparisons with p-values ≤ 0.05. CD11c+pSTAT3- cells and dual CD11c+CD163+pSTAT3- cells are significantly higher relative to CD11c+pSTAT3+ cells (p=0.022) and CD11c+CD163+pSTAT3+ cells (p=0.015) respectively. The other immune cell populations do not show any significant difference. (B) In tumor stroma, pSTAT3- T cells (orange arrows) can be seen in tight proximity to CD11c+CD163+pSTAT3- cells (red arrows). (C) pSTAT3+ T cell isolated in tumor.