Fig. 4.
Treatment with aqueous extracts of different tobacco products leads to regulation of pro-inflammatory pathways in a dose-dependent manner. mRNA expression of ICAM1(A–B), VCAM1(C–D), SELE(E–F) and CCL2(G–H) under high and low laminar flow conditions were determined. max = maximum nicotine concentration (Table 2). Data are shown as mean (x-fold static time-matched controls) ± SD. Statistics: One-Way ANOVA, *p < 0.05 vs. static time-matched controls, #p < 0.05 vs. time-matched control (0 μg/ml nicotine, 1 respectively 30 dyn/cm2), §p < 0.05, n ≥ 3.