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Effects of KEAP1-NRF2 binding parameters on NRF2 responses in Model 3a. Effects of varying (A–B)k1 (k’1), (C–D)k1.1 (k’1.1), (E–F)k2.1 (k’2.1), and (G–H)k3 (k’3) on steady-state dose-response curves of NRF2tot (left panels) and NRF2free (right panels). Note ki = k'i for i = 1, 1.1, 2.1, or 3; ×0.1, ×1, and ×10 denote 0.1, 1, and 10 times default values.
