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. 2021 Sep 22;47:102139. doi: 10.1016/j.redox.2021.102139

Fig. 4.

Fig. 4

Effects of varying parameter k’3alone on NRF2 responses in Model 3a to test hinge-latch hypothesis - with k’6at default value. Dynamical changes of KEAP1_NRF2open_tot and KEAP1_NRF2closed_tot in response to a high level of CLASSI-V at 1000 nM starting at 0 min and in response to termination of NRF2 synthesis (by setting k0 = 0) starting at 500 min, when k’3 is (A) 0.1 and (C) 10 times of default value. Steady-state dose-response curves of KEAP1_NRF2open_tot and KEAP1_NRF2closed_tot when k’3 is (B) 0.1 and (D) 10 times of default value. (E–F) Effects of varying k’3 on steady-state dose-response curves of NRF2tot and NRF2free respectively.