Table 4.
Correlation Analyses Between LILRB3 and LILRB5 mRNA Expression and Proinflammatory and Mucosal Injury Markers in iCD Patients Stratified by Endoscopic Severity and LILRB3 Expression
| LILRB3 | S100A9 | IL1B | IL17A | IL17B | IL21 | TNF | IL6 | LILRB5 | ||
|---|---|---|---|---|---|---|---|---|---|---|
| LILRB3 | Pearson correlation | 1 | .929∗∗ | .863∗∗ | .730∗∗ | 0.112 | .454∗∗ | .843∗∗ | .842∗∗ | -0.195 |
| Signficance (2-tailed) | P < .005 | P < .005 | P < .005 | 0.339 | P < .005 | P < .005 | P < .005 | 0.093 | ||
| N | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | |
| LILRB5 | Pearson correlation | -0.195 | -0.177 | -0.163 | -0.191 | -0.181 | -.234∗ | -0.157 | -0.11 | 1 |
| Sig. (2-tailed) | 0.093 | 0.129 | 0.163 | 0.101 | 0.12 | 0.044 | 0.179 | 0.346 | ||
| N | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | |
NOTE. LILRB3 quartiles were established based on RPKM values: quartiles Q1 (0%–25%), 0.59–1.44; Q2 (26%–50%), 1.48–2.72; Q3 (51%–75%), 2.73–5.47; and Q4 (76%–100%), 5.56–73.39). Statistical analysis was performed using SPSS 17.0. The frequencies procedure was used for the LILRB3 quartile analysis. The χ2 test was used to assess the association of CD categories with 4 LILRB3 quartiles. The association of LILRB3 with Th17 pathway associated genes IL1B, IL17A, IL21, TNF, IL6, and S100A9 was evaluated by the Pearson correlation as quantitative variables. ∗∗P < .01.