Table 3. Univariate analysis of factors associated with stroke recurrences.
CAA-related ICH ( n = 60) | HTN-related ICH ( n = 103) | |||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Baseline clinical characteristics | ||||
Age | 0.964 (0.893-1.041) | 0.352 | 1.032 (0.985-1.081) | 0.186 |
Male | 2.073 (0.495-8.677) | 0.318 | 1.226 (0.401-3.748) | 0.721 |
Hypertension | 0.577 (0.138-2.413) | 0.451 | / | / |
Diabetes mellitus | 1.861 (0.375-9.227) | 0.447 | 0.632 (0.174-2.298) | 0.486 |
Dyslipidemia | 1.223 (0.142-7.537) | 0.637 | 0.728 (0.331-1.601) | 0.429 |
Previous stroke | 0.494 (0.061-4.016) | 0.510 | 1.700 (0.377-7.678) | 0.490 |
Antiplatelet use | 0.756 (0.222-4.078) | 0.529 | 0.576 (0.067-5.387) | 0.689 |
Statin use | 1.275 (0.653-4.338) | 0.264 | 0.835 (0.321-3.965) | 0.189 |
Admission NIHSS | 1.116 (0.960-1.297) | 0.153 | 1.124 (0.986-1.280) | 0.081 |
Admission GCS | 0.749 (0.223-2.519) | 0.641 | 0.728 (0.331-1.601) | 0.429 |
Hematoma volume | 1.033 (1.001-1.066) | 0.045 | 1.012 (0.950-1.079) | 0.710 |
Imaging markers of CVSD | ||||
Lacunes | 2.120 (0.428-10.510) | 0.357 | 6.132 (2.054-18.311) | 0.001 |
CMBs | 1.108 (0.892-1.376) | 0.354 | 0.797 (0.258-2.455) | 0.692 |
EPVS | 0.771 (0.184-3.227) | 0.722 | 1.957 (0.658-5.825) | 0.228 |
WMH | 1.376 (0.936-2.024) | 0.105 | 1.251 (0.965-1.622) | 0.091 |
cSS | 1.979 (0.941-4.160) | 0.072 | 2.176 (0.747-6.343) | 0.154 |
The original SVD score | 2.449 (1.076-5.575) | 0.033 | 1.911 (1.193-3.061) | 0.007 |
The modified SVD score | 1.904 (1.051-3.448) | 0.034 | 1.586 (1.047-2.403) | 0.030 |
The refined SVD score | / | / | 1.589 (1.007-2.507) | 0.047 |
The CAA-SVD score | 1.894 (1.216-2.950) | 0.005 | / | / |
Total number of SVD markers | 3.839 (1.505-9.794) | 0.005 | 2.136 (1.218-3.745) | 0.008 |
Abbreviation: HTN = Hypertension; CAA = Cerebral Amyloid Angiopathy; ICH = Intracerebral Hemorrhage; NIHSS = National Institutes of Health Stroke Scale; GCS = Glasgow Coma Scale; cSS = Cortical Superficial Siderosis; CMBs = Cerebral Microbleeds; WMHs = White Matter Hyperintensities; EPVSs = Enlarged Perivascular Spaces; CSO = Centrum Semiovale ; BG = Basal Ganglia; SVD = Small Vessel Disease.