Supplementary Table 2-2. Percent change from baseline of PNs in subclasses of lipoproteins evaluated by GP-HPLC and NMR.
| Placebo | Pemafibrate | Fenofibrate | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.025 mg BID | 0.05 mg BID | 0.1 mg BID | 0.2 mg BID | 100 mg QD | |||||||||
| Mean(SD) | P value | Mean(SD) | P value | Mean(SD) | P value | Mean(SD) | P value | Mean(SD) | P value | Mean(SD) | P value | ||
| GP-HPLC | |||||||||||||
| CM | Week 0 | 4.9(4.2) | 4.5(3.5) | 4.1(3.3) | 4.2(3.1) | 3.3(3.3) | 3.9(2.4) | ||||||
| nM | Week 12 | 5.2(3.6) | 1.6(1.4) | 1.7(2.0) | 1.3(1.6) | 0.8(1.1) | 1.6(1.2) | ||||||
| % Change | 43.2(99.7) | 0.0150 | -41.6(83.7) | 0.0075 | -47.8(49.5) | 0.0000 | -66.2(31.4) | 0.0000 | -61.3(52.2) | 0.0000 | -44.5(46.9) | 0.0000 | |
| Large VLDL | Week 0 | 109.8(29.3) | 101.3(25.6) | 105.9(27.4) | 104.2(30.6) | 106.0(28.2) | 109.2(29.1) | ||||||
| nM | Week 12 | 113.5(41.5) | 77.4(24.9) | 68.0(28.0) | 60.8(25.5) | 56.3(21.3) | 77.4(26.6) | ||||||
| % Change | 5.1(31.6) | 0.3426 | -22.6(20.5) | 0.0000 | -35.2(21.9) | 0.0000 | -39.8(25.7) | 0.0000 | -43.5(27.1) | 0.0000 | -27.5(22.9) | 0.0000 | |
| Medium | Week 0 | 79.6(16.1) | 79.0(16.4) | 81.2(19.1) | 79.6(19.1) | 88.4(19.9) | 85.3(13.8) | ||||||
| VLDL | Week 12 | 81.8(21.9) | 69.3(13.1) | 59.7(14.8) | 59.5(16.4) | 60.7(16.8) | 68.1(14.7) | ||||||
| nM | % Change | 3.0(21.2) | 0.4126 | -9.6(22.5) | 0.0196 | -24.8(18.0) | 0.0000 | -24.2(18.0) | 0.0000 | -29.4(21.7) | 0.0000 | -19.5(15.9) | 0.0000 |
| Small VLDL | Week 0 | 54.1(11.9) | 55.8(13.8) | 57.1(17.3) | 53.0(13.3) | 63.6(15.1) | 58.4(10.6) | ||||||
| nM | Week 12 | 56.3(12.1) | 53.7(12.9) | 53.1(16.4) | 54.1(15.2) | 63.4(18.6) | 55.0(11.7) | ||||||
| % Change | 5.6(18.6) | 0.0827 | -1.7(20.4) | 0.6261 | -5.8(16.8) | 0.0444 | 2.5(16.6) | 0.3710 | 1.9(27.7) | 0.6941 | -4.9(17.9) | 0.1077 | |
| Large LDL | Week 0 | 192.8(43.7) | 196.0(54.4) | 195.5(58.8) | 192.7(45.1) | 227.4(55.4) | 204.2(41.0) | ||||||
| nM | Week 12 | 188.4(43.6) | 222.3(52.9) | 219.9(62.1) | 238.3(54.1) | 288.9(65.2) | 231.7(47.0) | ||||||
| % Change | -1.3(15.2) | 0.6041 | 16.3(24.0) | 0.0004 | 14.4(19.5) | 0.0001 | 25.5(20.4) | 0.0000 | 31.5(32.5) | 0.0000 | 15.2(21.0) | 0.0001 | |
| Medium LDL | Week 0 | 619.0(144.1) | 612.9(148.7) | 592.8(156.4) | 628.4(169.8) | 688.7(133.5) | 642.7(163.2) | ||||||
| nM | Week 12 | 588.3(145.7) | 654.2(128.7) | 618.9(138.9) | 654.8(146.3) | 735.2(128.3) | 672.7(159.6) | ||||||
| % Change | -4.6(11.0) | 0.0195 | 9.0(16.8) | 0.0042 | 7.4(22.9) | 0.0557 | 7.5(21.4) | 0.0435 | 8.6(19.2) | 0.0125 | 6.3(15.7) | 0.0209 | |
| Small LDL | Week 0 | 514.1(113.7) | 510.5(97.7) | 476.0(107.7) | 523.7(155.0) | 552.5(113.8) | 523.3(140.1) | ||||||
| nM | Week 12 | 499.5(116.8) | 478.1(90.3) | 422.8(113.6) | 430.8(132.3) | 445.0(97.1) | 469.3(116.8) | ||||||
| % Change | -2.2(13.2) | 0.3210 | -5.2(14.2) | 0.0416 | -9.8(20.7) | 0.0066 | -14.7(23.7) | 0.0007 | -18.2(16.3) | 0.0000 | -7.8(20.0) | 0.0243 | |
| Very Small | Week 0 | 331.4(75.1) | 334.1(66.9) | 304.2(68.7) | 333.4(94.8) | 348.4(79.8) | 334.0(91.1) | ||||||
| LDL | Week 12 | 327.5(77.2) | 291.3(61.6) | 249.0(68.6) | 255.9(84.6) | 260.8(58.6) | 284.3(76.5) | ||||||
| nM | % Change | 0.2(16.7) | 0.9440 | -12.0(13.2) | 0.0000 | -17.3(17.5) | 0.0000 | -21.2(20.9) | 0.0000 | -23.3(17.3) | 0.0000 | -12.7(20.5) | 0.0007 |
| Very Large | Week 0 | 189.5(33.3) | 204.5(45.0) | 194.7(41.6) | 193.9(40.0) | 195.0(35.4) | 196.1(35.0) | ||||||
| HDL | Week 12 | 191.9(41.9) | 173.6(31.8) | 170.2(43.1) | 159.3(30.0) | 160.9(26.0) | 168.4(28.1) | ||||||
| nM | % Change | 2.6(21.1) | 0.4707 | -13.5(14.0) | 0.0000 | -11.9(13.7) | 0.0000 | -16.3(14.4) | 0.0000 | -16.1(15.0) | 0.0000 | -12.8(14.1) | 0.0000 |
| Large HDL | Week 0 | 615.7(208.7) | 791.5(378.5) | 741.1(295.8) | 684.6(328.3) | 705.7(238.4) | 701.0(227.7) | ||||||
| nM | Week 12 | 623.5(257.7) | 711.4(362.0) | 703.8(346.1) | 562.5(293.2) | 581.2(215.5) | 598.4(231.3) | ||||||
| % Change | 2.4(29.6) | 0.6416 | -9.8(21.9) | 0.0152 | -5.7(21.1) | 0.1099 | -16.1(22.9) | 0.0002 | -15.6(22.5) | 0.0003 | -11.2(25.0) | 0.0108 | |
| Medium HDL | Week 0 | 3031(571.3) | 3224(606.8) | 3282(597.7) | 3251(682.4) | 3170(561.5) | 3175(545.6) | ||||||
| nM | Week 12 | 3137(558.1) | 3474(833.0) | 3574(766.0) | 3529(812.4) | 3691(842.9) | 3390(771.2) | ||||||
| % Change | 5.0(15.4) | 0.0650 | 7.5(14.6) | 0.0060 | 9.5(16.2) | 0.0011 | 9.5(17.5) | 0.0026 | 17.3(21.5) | 0.0000 | 6.6(14.3) | 0.0087 | |
| Small HDL | Week 0 | 5720(903.2) | 5492(770.8) | 5597(763.4) | 5726(1027) | 5552(700.3) | 5414(866.0) | ||||||
| nM | Week 12 | 5775(910.0) | 5933(930.5) | 6116(896.8) | 6545(1319) | 6632(1109) | 6214(1201) | ||||||
| % Change | 1.5(10.1) | 0.4008 | 8.3(11.9) | 0.0003 | 9.7(11.3) | 0.0000 | 14.4(12.1) | 0.0000 | 19.9(16.8) | 0.0000 | 14.9(13.7) | 0.0000 | |
| Very Small | Week 0 | 3732(595.5) | 3631(586.5) | 3524(573.1) | 3617(572.2) | 3607(520.3) | 3481(663.5) | ||||||
| HDL | Week 12 | 3690(596.4) | 3779(698.3) | 3730(702.0) | 3984(620.6) | 4111(642.0) | 3923(621.1) | ||||||
| nM | % Change | -0.3(13.9) | 0.9135 | 4.7(16.5) | 0.1084 | 6.4(14.4) | 0.0104 | 11.2(14.3) | 0.0000 | 15.5(20.7) | 0.0001 | 14.5(17.6) | 0.0000 |
| NMR | |||||||||||||
| CM & Large | Week 0 | 18.0(13.8) | 14.2(9.9) | 14.6(12.3) | 15.6(12.5) | 11.8(9.7) | 14.5(12.5) | ||||||
| VLDL | Week 12 | 18.2(13.8) | 7.1(6.3) | 8.5(8.6) | 6.8(6.4) | 5.2(4.8) | 7.6(6.0) | ||||||
| nM | % Change | 59.3(204.7) | 0.0957 | -0.7(152.1) | 0.9806 | 23.5(181.7) | 0.4425 | 13.7(294.2) | 0.7851 | -14.3(115.8) | 0.4709 | 105.1(768.2) | 0.4238 |
| Medium | Week 0 | 67.8(29.8) | 70.0(37.7) | 65.5(26.7) | 64.6(26.8) | 69.4(38.8) | 71.9(36.9) | ||||||
| VLDL | Week 12 | 68.8(41.8) | 47.7(22.9) | 36.0(21.5) | 28.8(15.4) | 23.1(14.1) | 46.4(26.0) | ||||||
| nM | % Change | 10.4(64.7) | 0.3473 | -24.6(42.1) | 0.0021 | -41.7(31.8) | 0.0000 | -51.6(27.1) | 0.0000 | -47.3(82.5) | 0.0021 | -14.9(106.5) | 0.4053 |
| Small VLDL | Week 0 | 34.0(25.8) | 38.0(30.1) | 42.6(32.6) | 36.7(26.7) | 49.2(44.1) | 49.0(28.3) | ||||||
| nM | Week 12 | 37.0(27.2) | 39.7(25.9) | 27.3(18.8) | 29.1(18.7) | 29.3(22.1) | 39.2(23.9) | ||||||
| % Change | 81.0(197.9) | 0.0230 | 138.4(392.4) | 0.0512 | -2.5(125.9) | 0.9044 | 131.6(624.7) | 0.2146 | 32.0(250.5) | 0.4554 | 82.8(379.5) | 0.2053 | |
| IDL | Week 0 | 236.0(158.0) | 245.2(141.4) | 217.4(122.5) | 204.1(154.8) | 263.5(173.4) | 244.3(151.5) | ||||||
| nM | Week 12 | 196.5(141.9) | 172.5(106.4) | 166.8(99.6) | 131.4(96.8) | 158.9(88.0) | 192.4(153.6) | ||||||
| % Change | 76.4(349.6) | 0.2049 | 15.2(203.6) | 0.6700 | 2.5(102.5) | 0.8812 | 26.1(264.1) | 0.5569 | 62.5(420.4) | 0.3849 | 53.3(340.9) | 0.3613 | |
| Large LDL | Week 0 | 179.6(185.7) | 208.4(210.9) | 218.7(201.7) | 229.1(226.9) | 274.2(241.5) | 182.3(196.5) | ||||||
| nM | Week 12 | 162.1(178.5) | 398.9(248.0) | 414.7(253.9) | 492.9(251.7) | 653.9(257.9) | 469.0(222.9) | ||||||
| % Change | 39.1(194.5) | 0.2882 | 522.2(1535.3) | 0.0636 | 404.2(1096.2) | 0.0489 | 324.5(450.1) | 0.0003 | 444.4(847.2) | 0.0066 | 659.5(1353.0) | 0.0097 | |
| Small LDL | Week 0 | 1078(274.9) | 1043(354.0) | 992.1(268.5) | 1087(298.0) | 1112(293.2) | 1071(298.6) | ||||||
| nM | Week 12 | 1072(277.6) | 950.9(309.4) | 806.1(325.6) | 856.6(282.3) | 833.1(295.3) | 872.8(216.5) | ||||||
| % Change | 2.6(26.1) | 0.5549 | 7.3(79.0) | 0.6005 | -15.2(35.6) | 0.0134 | -16.9(30.9) | 0.0024 | -15.2(50.7) | 0.0851 | -13.3(30.2) | 0.0124 | |
| Large HDL | Week 0 | 2546(1193) | 3558(2065) | 3051(1495) | 2917(1473) | 2791(1380) | 2944(1053) | ||||||
| nM | Week 12 | 2743(1301) | 3276(1682) | 2922(1466) | 2281(971.0) | 2409(1141) | 2397(1100) | ||||||
| % Change | 24.9(84.6) | 0.0904 | 0.3(40.9) | 0.9626 | 3.7(45.3) | 0.6202 | -13.1(36.6) | 0.0386 | -2.5(49.2) | 0.7678 | -9.8(52.2) | 0.2654 | |
| Medium | Week 0 | 6954(2549) | 7273(3251) | 8427(4578) | 7333(4020) | 8511(2904) | 8214(3435) | ||||||
| HDL | Week 12 | 7717(3510) | 7964(4657) | 9768(5556) | 10142(5855) | 10706(5105) | 9011(5104) | ||||||
| nM | % Change | 19.2(59.6) | 0.0644 | 41.1(142.7) | 0.1079 | 26.3(62.9) | 0.0155 | 60.4(105.6) | 0.0015 | 33.5(83.2) | 0.0231 | 12.8(48.1) | 0.1193 |
| Small HDL | Week 0 | 21606(4293) | 20439(4013) | 19873(3422) | 21464(4543) | 19789(3729) | 19292(4043) | ||||||
| nM | Week 12 | 21840(4020) | 22482(5688) | 21730(4653) | 23275(5079) | 24203(4852) | 22439(4477) | ||||||
| % Change | 2.9(17.5) | 0.3414 | 10.3(18.5) | 0.0030 | 10.3(20.1) | 0.0037 | 10.6(21.5) | 0.0057 | 23.2(30.2) | 0.0001 | 18.9(24.3) | 0.0000 | |