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. 2021 Oct 13;24(6):851. doi: 10.3892/mmr.2021.12491

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Copyright: © Niu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effect of PU on the GM-induced permeability of the mitochondrial membrane in HEI-OC1 cells. Red fluorescence represents the mitochondrial aggregated form of JC-1, indicating intact mitochondrial membrane potential. Green fluorescence represents the monomeric form of JC-1, indicating dissipation of the ΔΨm. (A) Representative photographs of JC-1 staining in different groups. Scale bar, 200 µm. (B) Flow cytometry study of the mitochondrial membrane potential. (C) Mitochondrial membrane potential analysis. n=6. **P<0.01. (D) Expression of Cyto C in the mitochondria and cytoplasm of HEI-OC1 cells as determined by western blotting. (E) Statistical analysis of protein expression in each group. n=6. **P<0.01. PU, puerarin; GM, gentamicin; HEI-OC1, House Ear Institute-Organ of Corti 1; Cyto C, cytochrome c.