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. 2021 Oct 8;12:719290. doi: 10.3389/fphar.2021.719290

FIGURE 2.

FIGURE 2

The effect of rAAV6-BMP7 gene therapy on diabetes-induced LV diastolic dysfunction. Doppler echocardiography was used to derive (A) peak E wave velocity, (B) peak A wave velocity, (C) E/A ratio, (D) peak e’ wave velocity, (E) peak a’ wave velocity, (F) e’/a’ ratio, (G) E/e’ ratio, (H) isovolumic relaxation time (IVRT), (I) deceleration time, as depicted in the (J) representative images. Data are presented as mean ± SEM. n = 10–21 per group (see individual data points). *p < 0.05, **p < 0.01, ***p < 0.001. Two-way ANOVA followed by Tukey’s post hoc test. AAV, adeno-associated virus; BMP7, bone morphogenetic protein 7.