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. 2021 Oct 8;12:755140. doi: 10.3389/fphar.2021.755140

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Copyright © 2021 Wang, Su, Yu, Yan, Shi, Huang, Li, Wu, Xia, Li, Chen and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BUDE on the blood pressure of the model rats. (A) Changes in the systolic blood pressure (SBP). (B) Changes in the diastolic blood pressure (DBP). (C) Changes in the mean blood pressure (MBP). Compared with the normal control group ^# p < 0.05, ^## p < 0.01; compared with the model control group ^* p < 0.05, ^** p < 0.01, n = 8–10. NG: normal control group; MG: ACHSFDs model group; VAL: valsartan group; BUDE-L: BUDE low-dose group; BUDE-H: BUDE high-dose group.