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. 2021 Oct 8;12:755140. doi: 10.3389/fphar.2021.755140

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Copyright © 2021 Wang, Su, Yu, Yan, Shi, Huang, Li, Wu, Xia, Li, Chen and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BUDE on vascular endothelial. (A) Changes in the plasma nitric oxide (NO). (B) Changes in the plasma endothelin 1 (ET-1). (C) Changes in the plasma endothelial nitric oxide synthase (eNOS). (D) Representative graph ( × 40, × 400) of H&E staining of the vessels: shedding of endothelial cells (red arrow) and smooth muscle cell hypertrophy (black arrow). (E) Vessel ultrastructure by scanning electron microscopy (SEM) observed at magnification 1,000× and 2000×. Compared with the normal control group ^# p < 0.05, ^## p < 0.01; compared with the model control group ^* p < 0.05, ^** p < 0.01, n = 9.