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. 2021 Oct 8;12:755140. doi: 10.3389/fphar.2021.755140

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Copyright © 2021 Wang, Su, Yu, Yan, Shi, Huang, Li, Wu, Xia, Li, Chen and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BUDE on the TLR4/MyD88 pathway in the vessel. (A) Immunohistochemical staining of TLR4 in the vessel (100×, 200×). (B) Changes in the plasma tumor necrosis factor-α (TNF-α) (C) Changes in the plasma interleukin-6 (IL-6). (D-F, H) Western blot assaying on the levels of TLR4, MyD88, IKKβ and phosphorylation, IKBα and phosphorylation, p65 and phosphorylation in the vessel (G) Relative expressions of TLR4 and MyD88 mRNA. Compared with the normal control group ^# p < 0.05, ^## p < 0.01; compared with the model control group ^* p < 0.05, ^** p < 0.01, n = 3, 9.