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. 2021 Oct 8;12:755140. doi: 10.3389/fphar.2021.755140

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Copyright © 2021 Wang, Su, Yu, Yan, Shi, Huang, Li, Wu, Xia, Li, Chen and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BUDE on intestinal barrier. (A) Representative graph (×200) of hematoxylin and eosin staining of the colon: shedding of colonic villi (blue arrow) and a small amount of inflammatory cell infiltration (red arrow) (B) Colon ultrastructure by transmission electron microscopy (TEM) observed at magnification × 20000: Villi loss (red arrow) and tight junction protein damage (blue arrow). (C) Representative figures of immunohistochemical staining of claudin-1 in the colon (×200). (D) Representative charts of immunohistochemical staining of occludin in the colon (×200). (E) Changes in the plasma d-lactic acid (D-LA). (F) Changes in the plasma lipopolysaccharide (LPS). Compared with the normal control group ^# p < 0.05, ^## p < 0.01; compared with the model control group ^* p < 0.05, ^** p < 0.01, n = 3, 9.