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Experiment protocol blueprints. This schematic diagram shows the mechanism of over-consumption of alcohol, and high sugar and fat diets (ACHSFDs) leading to metabolic hypertension (MH). BUDE regulated intestinal flora and improved the intestinal barrier, so as to reduce LPS production and infiltration into the blood circulation, inhibited the activation of the enteric-origin LPS/TLR4 pathway, and improved vascular endothelial function, thereby improving MH.
