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. 2021 Oct 21;138(16):1465–1480. doi: 10.1182/blood.2020009871

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© 2021 by The American Society of Hematology

This article is made available via the PMC Open Access Subset for unrestricted reuse and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 3. — Maturation of NK cells into cytotoxic effectors is perturbed in PBMCs from patients with B/T-ALL. Flow cytometry analysis of NK cells showing the percentages of CD94⁻, CD56^brightCD94⁺, CD56^dimCD94^High, and CD56^dimCD94^Low NK cells (A-B), KIR2DL1⁺ total NK cells and CD56^brightKIR2DL1⁺ and CD56^dimKIR2DL1⁺ NK cells (C-D), CD11b⁻CD27⁻, CD11b⁻CD27⁺, CD11b⁺CD27⁺, and CD11b⁺CD27⁻ NK cells (E-F) in PBMCs from healthy donors (n = 9) and B/T-ALL patients (n = 9). (G-H) Flow cytometry analysis of NK cells showing the percentages of DNAM-1⁺ total NK cells and CD56^brightDNAM-1⁺, CD56^dimDNAM-1⁺, and CD56^dimDNAM-1⁻NK cells in PBMCs from healthy donors (n = 6) and B/T-ALL patients (n = 6). Graphs show median ± interquartile range. Gates for each marker were set using fluorescence − 1 (FMO) controls. Exact P values were calculated using the Mann-Whitney U test. ns, nonsignificant.