TABLE 4.
Results of sensitivity, specificity, and positive and negative predictive values according to the different panelsa
Panel | Serological status | EBNA p72 IgG
|
VCA p23 IgG
|
VCA p23 IgM
|
Concordance of interpretation (%) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV | |||
A | Seronegative | 100 | 100 | 100 | 100 | 97.4 | 100 | 97.4 | ||||||
B | Past infection | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||||||
C | Reactivation | 91.6 | 100 | 100 | 100 | 35.7 | 100 | 85.7 | ||||||
D | Primary infection | 100 | 97.2 | 51.4 | 100 | 75.6 | 100 | 94.5 | ||||||
E | Interference | 92.8 | 92.8 | 100 | 100 | 94.7 | 94.7 | 90.4 | ||||||
F | Routine diagnosis | 90.2 | 97.3 | 100 | 100 | 80.4 | 100 | 89.3 | ||||||
G | Past infection without EBNA | 81.8 | 100 | 97 | 100 | 70.5 | 100 | 61.8 | ||||||
Total | 92.6 | 95 | 93.2 | 95.1 | 89.5 | 100 | 100 | 82.5 | 75 | 85.7 | 49.1 | 94.8 |
PPV, positive predictive value; NPV, negative predictive value.