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. 2021 Oct 21;26:44. doi: 10.1186/s11658-021-00287-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Development of the senescence-associated secretory phenotype (SASP) in DIPS cells. Changes in mRNA of arbitrarily selected targets, as quantified according to RT-qPCR (a). Changes in the secretion of respective proteins into the environment (conditioned medium), as quantified by ELISA (b). The results are based on 6–8 independent experiments using HGSOCs obtained from different patients. The results are expressed as the means ± SEM. *p < 0.05 vs. young cells