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. 2021 Oct 21;19:332. doi: 10.1186/s12951-021-01077-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — MiR-183-5p is enriched in Hemin-MSC-EXO and has protective effects on SD/H-induced NMCM injury. A RNA-seq analysis showed the differential expression of miRNAs between MSC-EXO and Hemin-MSC-EXO. B The top 10 highly-expressed miRNAs in Hemin-MSC-EXO were validated by qPCR. C Quantification of miR-183-5p expression in Hemin-pretreated MSCs and miR-183-5p^KD-Hemin-MSC. D Quantification of miR-183-5p expression in Hemin-MSC-EXO and miR-183-5p^KD-Hemin-MSC-EXO. E Quantitative analysis of mitochondrial fragmentation in NMCM treated with Hemin-MSC-EXO and miR-183-5p^KD-Hemin-MSC-EXO under SD/H challenge. F Quantitative analysis of SA-β-Gal staining in NMCM treated with Hemin-MSC-EXO and miR-183-5p^KD-Hemin-MSC-EXO under SD/H challenge. SD/H means serum deprivation/hypoxia. n = 3 biological replicates for each group. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001