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. 2021 Oct 21;18:243. doi: 10.1186/s12974-021-02299-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — MiR-204-5p inhibits the occurrence of oxidative stress within the hippocampal DG region via the RGS12/Nrf2-NF-κB pathway. A Representative images of RGS12 (red) and MAP2 (green) staining. Nuclei (blue) are stained with DAPI. Scale bar is 50 μm. (N = 6 per group) B, C Representative western blot images showing relative protein levels of RGS12, Nrf2, NQO1, HO-1 and NF-κB p65 in AAV-miR-204-5p sponge virus infected DGs (N = 6 per group). (D-E) Representative western blot images showing relative protein levels in AAV-miR-204-5p virus infected DGs (N = 6 per group). **P < 0.01 ***P < 0.001, ****P < 0.0001, control + AAV-control vs control + AAV-miR-204-5p sponge; ^&&P < 0.01, ^&&&P < 0.001, ^&&&&P < 0.0001, CUS + AAV-control vs CUS + AAV-miR-204-5p. Data are presented as means ± SEMs. Student t-tests were employed for comparisons between the two groups. Two-way ANOVA was used for Fig. 6A. One-way ANOVA followed by Tukey’s post-hoc test was used for C and E