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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2021 Sep 10;30(11):106082. doi: 10.1016/j.jstrokecerebrovasdis.2021.106082

Table 3:

Studies Measuring Post-Stroke Depression in ICH Patients.

Studies Koivunen2 DASH3 FAST4 MISTIE III
Location Finland USA (State: California) 122 sites in 22 countries 78 sites in 9 countries
Study type Prospective Prospective Prospective Prospective
Overall study duration 10 years 365 days 90 days 365 days
Total sample analyzed 130 89 596 308
Time of PSD measurement Every year 365 days 90 days 180 days
Prevalence of PSD 30 (23.1%) 13 (15%) 120 (20%) 111 (36%)
PSD measures

  • HADSa

  • BDI-IIb

  • HDRSc

  • HDRSc

  • CES-Dg
Univariate analysis: statistically significant predictors of PSD

  • Hydrocephalus

  • BPId and PASSe

  • Employment status

  • Anticoagulation (admit)

  • mRS 0–1 vs 2–5 at 1 year

  • Change in mRS (day 90 to 1 year)

  • History of comorbidity

  • Female gender

  • Baseline ICH volume

  • Midline shift presence

  • Day 15 assessments: GCS, BI, NIHSS, and mRS 0–1, 2–3, vs. 4–5

  • Use of antidepressants

  • EQ-VAS

  • Hispanic/Latino ethnicity

  • Presence of IVH

  • ICH right hemisphere

  • NIHSS at randomization

  • Day 30 and 180 assessments: patient location, mRS 0–3 vs 4–5, EQ-VAS, impaired cognition, NIHSS, and BI score
Multivariable analysis: statistically significant predictors of PSD

  • Hydrocephalus

  • PASS score

  • Age

  • Anticoagulation

  • 1-year mRS

  • Female

  • History of comorbidity

  • Day 15 assessments: BI and NIHSS

  • Female

  • Hispanic/Latino ethnicity

  • Presence of IVH

  • ICH right hemisphere

  • Day 30 assessments: patient location and impaired cognition

Abbreviations: BDI-IIb: Beck Depression Inventory-II; BI = Barthel Index; BPId= Brief Pain Inventory; CES-Dg = Center for Epidemiologic Studies Depression Scale; EQ-VAS= EuroQol Visual Analogue Scale; GCS = Glasgow Coma Scale; HADSa = Hospital Anxiety and Depression Scale; HDRSc= Hamilton Depression Rating Scale; ICH = Intracerebral Hemorrhage; IVH = Intraventricular Hemorrhage; mRS = modified Rankin Scale; NIHSS = National Institute of Health Stroke Scale; PASSf= Pain Anxiety Symptom Scale; PSD = Post-stroke Depression