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. 2021 Oct 4;8:735485. doi: 10.3389/fcvm.2021.735485

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Copyright © 2021 Lu, Wang, Yu, Cui, Zhang, Ding and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treadmill exercise regulated microglia polarization through the JAK1/STAT6 pathway after MCAO. (A) The representative protein band of p-JAK1 and p-STAT6 was acquired by western blotting with the protein GAPDH serving as the control. Relative protein level of p-JAK1 (B) and p-STAT6 (C) in the penumbra on the 1st, 4th, and 7th day among the sham, MCAO and exercise groups are shown. Data are presented as the mean ± SD, n = 3/group. ^##P < 0.01 vs. sham group; *P < 0.05, **P < 0.01 vs. MCAO group.