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. 2021 Oct 22;22:297. doi: 10.1186/s13059-021-02513-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Genome-wide and surfaceome-wide screens for identification of host factors of RV. a Venn diagram showing the composition of surfaceome library. b Flow chart showing the procedures of genome-wide and surfaceome CRISPR screens. c Analyses of enriched sgRNA, or gene knockout, in genome-wide and surfaceome screens. d Analyses of the compositions of positive hits, as defined by a FDR of less than 0.01, in genome-wide and surfaceome screens. e Bubble plot showing the results of CRISPR screen. Top 10 candidate hits are shown. Significance of enrichment was calculated by MAGeCK