Table 2.
The pharmacokinetic parameters of danofloxacin (6 mg/kg; SC) alone or co-administered with meloxicam (1 mg/kg; SC) in healthy lambs (n = 6) and lambs with respiratory infections (n = 7). t1/2ʎz, terminal half-life; ClT/F, total clearance; Vdarea/F, volume of distribution; Vdss/F, volume of distribution in a steady state; Tmax, time to reach the peak concentration; Cmax, peak plasma concentration; AUC, area under the concentration–time curve; MRT, mean residence time; HD, healthy group who received danofloxacin alone; HDM, healthy group who received danofloxacin and meloxicam; ID, infected group who received danofloxacin alone; IDM, infected group who received danofloxacin and meloxicam.
| Parameters | HD | HDM | ID | IDM |
|---|---|---|---|---|
| t1/2ʎz (h) | 6.98 (5.75–8.15) | 6.46 (4.82–8.24) | 6.07 (5.01–7.48) | 6.73 (5.14–8.12) |
| ClT/F (L/h·kg) | 0.45 (0.39–0.51) a | 0.32 (0.28–0.36) b,c | 0.38 (0.31–0.42) b | 0.28 (0.21–0.31) c |
| Vdarea/F (L/kg) | 4.55 (3.52–5.40) a | 3.02 (2.01–4.18) b | 3.35 (2.98–4.20) a,b | 2.73 (1.94–3.44) b |
| Vdss/F (L/kg) | 2.46 (1.94–3.23) a | 1.88 (1.39–2.24) b | 2.12 (1.61–2.51) a,b | 1.70 (1.23–2.21) b |
| Tmax (h) | 1.01 (0.75–2.00) | 1.25 (1.00–2.00) | 1.34 (1.00–2.00) | 1.23 (0.75–2.00) |
| Cmax (µg/mL) | 3.36 (2.46–4.46) b | 3.73 (2.89–4.30) a,b | 3.61 (2.97–4.46) a,b | 4.59 (3.29–6.44) a |
| AUC0–24 (h.µg/mL) | 12.68 (11.04–14.61) c | 17.69 (15.94–20.32) a,b | 14.99 (13.59–17.97) b,c | 20.23 (18.37–25.93) a |
| AUC0–∞ (h·µg/mL) | 13.26 (11.63–15.26) c | 18.52 (16.56–20.73) a,b | 15.65 (13.96–19.06) b,c | 21.30 (19.19–27.29) a |
| Cmax/AUC | 0.25 (0.20–30) | 0.20 (0.15–0.25) | 0.23 (0.17–0.29) | 0.22 (0.17–27) |
| MRT (h) | 5.43 (4.54–6.27) | 5.81 (4.79–6.95) | 5.54 (3.86–6.78) | 6.02 (4.72–7.51) |
Data are presented as the geometric mean (min–max) and were analyzed by two-way ANOVA with Tukey’s test. a,b,c Different letters in the same row are statistically different (p < 0.05).