Table 4.
The PK/PD surrogate indices determined using the pharmacokinetic parameters obtained from the free concentrations of danofloxacin and the MIC values determined for the bacterial strains isolated from the lambs with respiratory infections. MIC, minimum inhibitor concentration; AUC, area under the concentration–time curve; Cmax, peak plasma concentration; GM, geometric mean; ID, infected group who received danofloxacin alone; IDM, infected group who received danofloxacin and meloxicam.
| Animal No | ƒAUC0–24/MIC | ƒCmax/MIC | ||
|---|---|---|---|---|
| ID | IDM | ID | IDM | |
| Mannheimia haemolytica, MIC90 of 0.25 µg/mL | ||||
| 1 | 38.42 | 57.62 | 7.99 | 10.32 |
| 2 | 37.83 | 44.98 | 10.89 | 13.35 |
| 3 | 36.50 | 81.31 | 9.34 | 20.21 |
| 4 | 29.70 | 59.95 | 11.99 | 11.26 |
| 5 | 50.42 | 56.37 | 10.43 | 19.17 |
| 6 | 59.97 | 58.85 | 8.66 | 14.76 |
| 7 | 44.08 | 60.90 | 9.15 | 14.45 |
| GM (min–max) | 41.44 (29.70–59.97) | 59.21 (44.98–81.31) | 9.69 (7.99–11.99) | 14.40 (10.32–20.21) |
| Escherichia coli , MIC of 0.125 µg/mL | ||||
| 1 | 76.84 | 115.23 | 15.98 | 20.65 |
| 2 | 75.66 | 89.96 | 21.78 | 26.69 |
| 3 | 73.01 | 162.63 | 18.69 | 40.42 |
| 4 | 59.40 | 119.89 | 23.98 | 22.53 |
| 5 | 100.83 | 112.74 | 20.86 | 38.33 |
| 6 | 119.94 | 117.71 | 17.31 | 29.53 |
| 7 | 88.16 | 121.80 | 18.30 | 28.90 |
| GM (min–max) | 82.89 (59.40–119.94) | 118.43 (89.96–162.63) | 19.39 (15.98–23.98) | 28.80 (20.65–40.42) |