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. 2021 Oct 7;10(10):1217. doi: 10.3390/antibiotics10101217

Figure 3.

Figure 3

Synergic activity of FK520 with triazoles, echinocandins, and cell wall-perturbing agents. POS, posaconazole; FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; CAS, caspofungin; MCF, micafungin; ANF, anidulafungin. (A) Disk diffusion of FK520 with triazoles: POS (10 μg), FLC (80 μg), ITC (80 μg), VRC (10 μg), without or with FK520 (20 μg). The inhibition zones of POS, FLC, ITC, and VRC combined with FK520 in ATCC2001, BMU10720, and BMU10722 were significantly larger than those of triazoles used alone. (B) Disk diffusion of FK520 with echinocandins: CAS (10 μg), MCF (10 μg), ANF (10 μg), without or with FK520 (20 μg). The inhibition zones of CAS, MCF, and ANF combined with FK520 in ATCC2001, BMU10720, and BMU10722 were significantly larger than those of echinocandins used alone.