Table 2.
Results of included observational cohort studies.
| Author(s)/ Year | Allergy Confirmation | Procedure | N 1/DI 2 | Failure Rates (at Implant Level) | Antibiotics Used | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| NA 3 | A 4 | NA | A | RI 5 | p6 (95%) | NA | A | |||
| Salomó-Coll et al. [16] (2018) | SRPA 7 | Ordinary implants in healthy patients | 1133/2572 | 77/175 | 8.03% | 24.68% | RR 8 3.84 |
0.032 | Amoxicillin 2g 9, 1h PreOp + 750 mg 10/8h 11/7d 12 PostOp | Clindamycin 600 mg, 1h PreOp + 300 mg/6h/7d PostOp |
| French et al. [17] (2016) | SRPA | Various types: ordinary implants, with simultaneous GBR 13, immediate and sinus lifts ASA I or II patients |
UNS 14/5106 | UNS 14/470 | 0.80% | 2.10% | OR 3.10 |
0.002 | Amoxicillin 2 g, 1h PreOp + 500 mg at 8h PostOp (If bone-grafting, immediate implant or sinus lift: 250 mg/8h/7d) | Clindamycin 600 mg/1h PreOp (If bone-grafting or immediate implant 150 mg/6h/7d. If sinus lift: levofloxacin 250 mg/12h/7d) |
| French et al. [19] (2015) | Preliminary test | Placement of implants in native bone with or without GBR, immediate implants and sinus lifts | 1898/UNS 14 | 162/UNS 14 | UNS 14 | UNS 14 | HR 2.16 |
0.11 | Amoxicillin (UNS 14 guidelines) | Clindamycin (UNS 14 guidelines) |
| Wagenberg and Froum [18] (2006) | SRPA | Placement of immediate implants, some with sinus lift and some with immediate loading | UNS 14/1561 | UNS 14/364 | 2.95% | 8.52% | RR 3.34 |
<0.001 | Amoxicillin 500 mg/6h/2d PreOp + 10d PostOp | Clindamycin 300 mg/6h/2d PreOp + 10d PostOp |
1 N, sample size; 2 DI, dental implants; 3 NA, not allergic to penicillin; 4 A, allergic to penicillin; 5 RI, risk indicator; 6 p, statistical significance at 95% confidence interval; 7 SRPA, self-reported penicillin allergy; 8 RR, relative risk; 9 g, gram; 10 mg, milligrams; 11 h, hour(s); 12 d, days; 13 GBR, guided bone regeneration; 14 UNS, unspecified.