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. 2021 Sep 29;10(10):1547. doi: 10.3390/antiox10101547

Figure 4.

Figure 4

Proliferative and migration phenotype of ECFCs isolated from patients with and without CAD. (A) Reconstructions of coronary arteries from CTCA showing extensive atherosclerosis (CAD+, right) compared to a healthy, non-diseased vessel (CAD−, left) and representative bright-field images of matrigel tube formation assay performed with ECFCs from patients with (CAD+) and without (CAD−) CAD. Scale bar = 500 µm. (B,C) Bar graph of tube formation assay data of ECFCs from patients with or without CAD classified by either CACS or Gensini score respectively. Results are presented as mean ± SEM. Sample size: CACS = 0, n = 18; CACS > 0, n = 18; Gensini = 0, n = 13; Gensini > 0, n = 23. (D,E) Time course of closure in scratch assays on confluent cell monolayers in 96 well plates, showing the closure rates of ECFCs from patients with or without CAD classified by either CACS or Gensini score respectively. Results are presented as mean percentage of closure ± SEM. Sample size: CACS = 0, n = 9; CACS > 0, n = 15; Gensini = 0, n = 6; Gensini > 0, n = 18. * p < 0.05.