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. 2021 Sep 26;10(10):1524. doi: 10.3390/antiox10101524

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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LO pathway, PGE₂ synthesis and signaling pathway. MAPK, mitogen-activated protein kinase; COX-2, cyclooxygenase-2; NFκB, nuclear factor-κB; ROS, reactive oxygen species; PGE₂, prostaglandin E2; DNP, dinitrophenyl; IgE, immunoglobulin E; FcεRI, high-affinity IgE receptor; Syk, spleen tyrosine kinase; PKC, protein kinase C; AA, arachidonic acid; 5-Lox, arachidonate 5-lipoxygenase; FLAP, 5-LO-activating protein; 5HPETE, 5-hydroperoxyeicosatetraenoic acid; LT, leukotriene; EC, endothelial cell; SMC, smooth muscle cell; CysLT1, cysteinyl leukotriene 1; EGCG, Epigallocatechin gallate.