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A model of Shp-2 function. It has been known that Shc, Grb2, and phosphoinositol 3-kinase (PI3K) are associated with Gab1 and are involved in mediating Ras activation following EGF treatment. Results from this work allow us to propose a novel mechanism for the role of Shp-2 in promoting the activation of the Ras-Erk pathway by EGF, possibly through dephosphorylation of Gab1-associated p90, which is indicated by arrows with dashed lines.
