Table 2.
Planned and actual doses (mg/kg) of tiletamine-zolazepam for the different treatments in pair-housed C57BL/6 mice.
| Treatment | Planned Dose | Actual Dose 1 | n 2 | |||
|---|---|---|---|---|---|---|
| Mean | Min | Max | SD | |||
| Control | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 40 |
| Z10 | 10.0 | 10.0 | 10.0 | 10.0 | 0.0 | 8 |
| Z20 | 20.0 | 20.0 | 20.0 | 20.0 | 0.0 | 8 |
| Z40 | 40.0 | 38.5 | 30.8 | 40.0 | 3.3 | 8 |
| Z80 | 80.0 | 58.1 | 10.4 | 77.6 | 23.2 | 8 |
| Z100 | 100.0 | 81.9 | 32.0 | 100.0 | 23.0 | 8 |
1 As dosage increased, mice did not always consume all cream cheese offered, reducing the amount of tiletamine-zolazepam (Zoletil®) consumed. 2 Each treatment contained 2 cages of female, pair-housed mice and 2 cages of male, pair-housed mice; each of these was matched with a randomly assigned control, resulting in a total of 8 control mice per treatment, and a total of 40 control mice for the entire study.