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. 2021 Oct 13;10(10):1240. doi: 10.3390/antibiotics10101240

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A). Effects of different irradiance ratios of aBL and aPDT in the dual-light aPDT system in three-day S. aureus biofilm, when the antibacterial treatment is given once daily. Three-day S. aureus biofilm, daily dose, aBL vs. dual-light 1:3 aBL/aPDT ratio, p = 0.0022; aBL vs. dual-light 1:1 aBL/aPDT ratio, p = 0.015; aBL vs. dual-light 3:1 aBL/aPDT ratio, p = 0.0022; aPDT vs. dual-light 1:3 aBL/aPDT ratio, p = 0.0043; aPDT vs. dual-light 1:1 aBL/aPDT ratio, p = 0.015; aPDT vs. dual-light 3:1 aBL/aPDT ratio, p = 0.0022; aBL vs. aPDT, p = 0.26; dual-light aPDT: 1:3 aBL/aPDT ratio vs. 1:1 aBL/aPDT ratio, p = 0.03; 1:3 aBL/aPDT ratio vs. 3:1 aBL/aPDT ratio, p = 0.0022; 1:1 aBL/aPDT ratio vs. 3:1 aBL/aPDT ratio; p = 0.0022. The y-axis displays the median of CFUs. Six assays were performed for each experiment, and the control biofilm was performed in three assays. The 95% confidence interval (CI) is presented by using t-bars. (B). A schematic representation of the experiment.