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. 2021 Oct 18;10(10):1638. doi: 10.3390/antiox10101638

Figure 8.

Figure 8

Isoquercitrin isolated from QA inhibits viral activity through ICP27 inhibition during HSV-1 infection. (A) SK-N-SH cells were infected with HSV GFP (MOI = 2) for 2 h and then treated with isoquercitrin (10 and 20 μM) for 48 h. HSV-GFP expression levels were analyzed by fluorescence microscopy (left) and flow cytometry (right). (B) SK-N-SH cells were infected with HSV-1 (MOI = 0.01) for 2 h and then treated with isoquercitrin at 10 and 20 μM and cultured for 48 h. Whole cell extracts were subjected to western blot analysis for VP16 and ICP27. β-Actin was used to confirm equal sample loading. The data are representative of three independent experiments and quantified as mean values ± SEM. One-way ANOVA with Tukey’s post hoc test; *** p < 0.001, compared with the HSV-1 sample.