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. 2021 Oct 15;10(10):1620. doi: 10.3390/antiox10101620

Figure 1.

Figure 1

Structure of SAC and experiment design (A) and protective effects of SAC on cisplatin-induced AKI in mice. SAC given to mice at a daily intraperitoneal (i.p.) dose of 5, 10 and 20 mg/kg over 10 days; SAC was administered first on day 7, followed 1 h later by cisplatin, and the mice were sacrificed on day 11. Blood BUN levels (B) and CRE levels (C). Kidneys stained with H&E (D) and the kidney injury scores (E). Each group’s kidneys were provided for histological evaluation. After H&E staining, representative histological sections were magnified (400×) and photographed. The values are reported as the mean ± SEM (n = 6). ### p < 0.001 compared with the control group. ** p < 0.01 and *** p < 0.001 compared with the cisplatin-only group. Arrows show tubular cell necrosis; scale bar = 50 μm.