Figure 4.

SAC inhibited the cisplatin-induced (A) iNOS, COX-2, (B) TLR-4, IκB-α and NF-κB, and (C) MAPK phosphorylation protein levels in mice with cisplatin-induced nephrotoxicity. Protein levels of iNOS, COX-2, TLR-4, IκB-α, NF-κB and MAPK phosphorylation protein expression in renal tissues were analyzed by Western blot after cisplatin induction. Protein bands were analyzed by densitometric analysis. The values are reported as the mean ± SEM (n = 3). ^### p < 0.001 compared with the control group. * p < 0.05, ** p < 0.01 and *** p < 0.001 compared with the cisplatin-only group.