Figure 8.

Effects of SAC and the Sirt1 inhibitor (EX-527) on cisplatin-induced nephrotoxicity. SAC and/or EX-527 given to mice at a daily intraperitoneal (i.p.) dose of 20 mg/kg and/or 10 mg/kg for 10 days; they were given cisplatin 20 mg/kg, i.p. 1 h after SAC and/or EX-527 administration on day 7 and were euthanized on day 11. (A) Experiment design, (B) blood BUN levels, (C) serum CRE levels, (D) kidneys stained with H&E and (E) the kidney injury scores. Each group’s kidneys were provided for histological evaluation. After staining, representative histological sections were magnified (400×) and photographed. The values are reported as the mean ± SEM (n = 6). ^### p < 0.001 compared with the control group. * p < 0.05, ** p < 0.01 and *** p < 0.001 compared with the cisplatin-only group. Arrows show tubular cell necrosis; scale bar = 50 μm.