Table 2.

SAC and the Sirt1 inhibitor (EX-527) change the body weight and the kidney index, showing resistance to cisplatin-associated nephrotoxicity. The values are reported as the mean ± SEM (n = 6). ^### p < 0.001 compared with the control group. ** p < 0.01 and *** p < 0.001 compared with the cisplatin-only group.

Groups	Initial Body (g)	Final Body (g)	Kidney Index (mg/g)
Control	33.78 ± 0.66	37.39 ± 1.08	1.44 ± 0.04
Cisplatin (20 mg/kg)	33.39 ± 0.30	32.41 ± 0.62 ###	2.46 ± 0.04 ###
Cisplatin (20 mg/kg) + SAC (20 mg/kg)	33.65 ± 0.30	34.96 ± 0.51 ***	1.55 ± 0.02 ***
Cisplatin (20 mg/kg) + EX-527 (10 mg/kg)	33.43 ± 0.33	32.86 ± 0.22	2.39 ± 0.04 **
Cisplatin (20 mg/kg) + SAC (20 mg/kg) + EX-527 (10 mg/kg)	33.46 ± 0.19	33.9 ± 0.58 **	1.69 ± 0.03 ***