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KRAS polybasic domain contributes to the selective sorting of lipid headgroups. The prenylation (15-carbon farnesyl or 20-carbon geranylgeranyl chain) and the polybasic domain of KRAS combine to contribute to the selectivity of lipid headgroups within KRAS nanoclusters. The constitutively active oncogenic mutant KRASG12V with different combinations of the prenyl anchors and the residues of polybasic domains selectively sort distinct lipid types with different headgroups.
