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. 2021 Oct 13;10(10):1608. doi: 10.3390/antiox10101608

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Activation of the coagulation cascade by sickle RBC-derived microparticles and tissue factors. Phosphatidylserine-positive microparticles (PS-positive MPs) derived from sickle RBCs and sickle RBC-free hemoglobin-induced tissue factor (TF) release enhances thrombosis in SCD by activating the coagulation cascade.