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. 2021 Sep 26;9(10):1319. doi: 10.3390/biomedicines9101319

Figure 6.

Figure 6

ML multi-gene classifiers exhibit a higher recall than single-gene markers in 23 of the 26 treatment-cancer type pairs. (A) In 12 of the 13 treatments for BRCA, multi-gene markers achieve a higher recall than the single-gene marker. The exception was the BGJ398-KIF20B association. (B) In 11 of the 13 treatments for CRC, multi-gene markers achieve a higher recall than the single-gene marker. These two single-gene markers with higher recall are the association BYL719-TMEM184A and the association BYL719+LJM716-LSR. Note that these three genes (KIF20B, TMEM184A and LSR) all have very high prevalence (47%, 61% and 85%, respectively) in addition to having the lowest p-value as a sensitive marker in their respective cancer types.