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. 2021 Oct 6;11(10):1470. doi: 10.3390/biom11101470

Figure 1.

Figure 1

RA reduces body weight and blood glucose levels in HFD-fed mice. C57BL/6 mice were fed an ND or HFD (60% kcal fat) for 8 weeks to induce diabetic conditions as described in the Methods section. Then, the mice were randomly assigned to the following groups: (1) the control group (ND, n = 10), (2) HFD group (n = 10), (3) HFD + 50 mg/kg rosmarinic acid group (n = 10), (4) HFD + 100 mg/kg rosmarinic acid group (n = 10), and (5) HFD + 100 mg/kg metformin group (n = 10). Rosmarinic acid and metformin were administered orally once a day for 8 weeks. (A) Experimental scheme to induce obesity and diabetes in C57BL/6 mice. (B) Body weights were measured twice a week, and final body weights before sacrifice are presented as the mean ± SD. (C,D) FGB levels (C) and OGTT values (D) after oral gavage of d-glucose (2 g/kg) were measured in blood samples obtained from the tail vein. The results are expressed as the mean ± SD. *** p < 0.001 vs. ND control mice; # p < 0.05, ### p < 0.001 vs. HFD mice.