Figure 6.

Schematic presentation by which RA induces cholesterol excretion and protects the liver in HFD-fed mice. A schematic diagram illustrating the protective mechanisms of rosmarinic acid against hyperlipidemia. Rosmarinic acid enhances reverse cholesterol transport (RCT) and lipid metabolism. Rosmarinic acid mediates RCT through increased plasma cholesterol uptake and subsequent hepatobiliary excretion and induces lipid metabolism by increasing fatty acid β-oxidation in AMPK-dependent activation of CPT1A, thus modulating lipid accumulation and attenuating hyperlipidemia in HFD-fed mice.