Table 3.

Analytical Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases.

Confounders	Summary	Reference
Within-Subject Correlation	CRP has positive associations with nighttime and 24-hour systolic BP variability	[102]
Reproducibility Issues	Serial measurements also occur due to variation in analytical methods and day-to-day inter- and intra-subject variations	[103]
Selection Bias	Research studies have shown the significant risk of selection bias in CRP measurement	[110]
Data Analysis Concerns	Transparent data management techniques are required to avoid non-detects and high-value outlier replication, and reproducibility issues	[111]