Table 2.
Main parameters (baseline and endpoint) evaluated in healthy (Sham; n = 3) and CKD (SNX; n = 4) animals 1.
| Parameter | Baseline | Endpoint | ||
|---|---|---|---|---|
| Healthy (Sham) | CKD (SNX) | Healthy (Sham) | CKD (SNX) | |
| Age (weeks) | 9 | 9 | 29 | 31 |
| Body weight (g) | 174.3 ± 10.7 | 182.5 ± 7.0 | 276.0 ± 16.0 ** | 293.0 ± 18.6 *** |
| Systolic blood pressure (SBP) (mmHg) | 120.7 ± 5.8 | 142.7 ± 16.0 | 128.0 ± 5.4 | 202.9 ± 18.8 *# |
| Hematocrit (%) | 41.3 ± 0.9 | 40.5 ± 0.7 | 42.7 ± 0.9 | 41.3 ± 1.0 |
| Plasma creatinine (µmol/L) | 33.9 ± 8.6 | 29.1 ± 3.8 | 34.3 ± 5.6 | 77.1 ± 9.9 **# |
| Urine creatinine (µmol/24 h) | 42.4 ± 1.2 | 39.2 ± 2.4 | 78.2 ± 10.7 | 89.1 ± 14.8 * |
| Plasma urea (mmol/L) | 5.1 ± 0.3 | 4.9 ± 0.4 | 6.7 ± 0.6 | 16.3 ± 2.8 **# |
| Urine Na+ (µmol/24 h) | 451.1 ± 88.2 | 386.4 ± 45.7 | 509.1 ± 48.3 | 540.9 ± 110.4 |
| Urine K+ (µmol/24 h) | 914.3 ± 81.6 | 773.9 ± 59.3 | 975.6 ± 133.0 | 1840.1 ± 353.7 * |
| Proteinuria (mg/24 h) | 2.3 ± 0.5 | 2.3 ± 0.3 | 2.1 ± 0.1 | 329.4 ± 55.9 ***### |
1 Age is presented as median, all the other parameters are presented as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 (Two-way ANOVA followed by Sidak’s multiple comparison test, using corresponding baseline values as controls); # p < 0.05, ### p < 0.001 (Two-way ANOVA followed by Sidak’s multiple comparison test, using corresponding Sham values as controls).