Figure 11.

Inhibition of 6-OHDA-induced cytotoxicity by the test compounds in PC12 cells. PC12 cells were pre-treated for 4 h with compound 7b (a), 8a (b), 8b (c), and 8e (d) or rasagiline at the indicated concentrations and subsequently exposed to 6-OHDA (50 μM) for an additional 24 h. Cell viability was evaluated by MTT assay as described in the Materials and methods. Data are expressed as the mean ± SEM of at least three independent experiments. * p < 0.05 and # p < 0.05 vs. the vehicle-treated control and 6-OHDA-treated cells, respectively. 6-OHDA, 6-hydroxydopamine.