Scheme 2.
Reagents and conditions: (a) H2SO4, methanol, reflux, overnight; (b) 3-fluorobenzoyl chloride, NaOH, TBAHS, DCM, rt, 2 h; (c) appropriate amine, HATU, DIPEA, DMF, 80 °C, overnight.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.