Table 2.
Inhibitory effects against MAO-A and the selectivity indices.
| MAO-A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cpd | Inhibition% (100 µM) | S.E.M | Inhibition% (30 µM) | S.E.M | Inhibition% (10 µM) | S.E.M | MAO-A IC50 (µM) | MAO-B IC50 (µM) | Selectivity Index (SI) a |
| 7b | <10 | 2.789 | <10 | 1.449 | <10 | 0.334 | >100 | 0.3278 | >305 |
| 8a | 23.48 | 21.66 | 21.66 | 0.920 | 17.16 | 0.687 | >100 | 0.0274 | >3649 |
| 8b | 30.07 | 1.474 | 27.88 | 0.965 | 15.07 | 0.764 | >100 | 0.0305 | >3278 |
| 8e | <10 | 1.959 | <10 | 1.009 | <10 | 0.689 | >100 | 0.4532 | >220 |
a SI = selectivity index, the selectivity for the MAO-B isoform and is given as the ratio of IC50 (MAO-A)/IC50 (MAO-B).