Table 3.
Changes in immune checkpoints and immune cell proportion according to treatment status of latent tuberculosis infection (n = 33 pairs). The data are shown in percentage.
| Before LTBI Treatment | After 12 Weeks of LTBI Treatment | p Value | |
|---|---|---|---|
| CD4+ cells in lymphocytes | 42.5 ± 11.2 | 36.6 ± 15.1 | 0.005 |
| TIM3 on CD4+ | 10.7 ± 5.6 | 7.2 ± 5.8 | 0.005 |
| PD-1 on CD4+ | 26.3 ± 11.8 | 24.1 ± 9.7 | 0.114 |
| CTLA-4 on CD4+ | 17.8 ± 7.4 | 12.9 ± 8.9 | 0.017 |
| CD8+ cells in lymphocytes | 23.5 ± 9.4 | 20.9 ± 11.4 | 0.120 |
| TIM3 on CD8+ | 16.0 ± 7.7 | 13.7 ± 8.9 | 0.138 |
| PD-1 on CD8+ | 31.1 ± 12.9 | 29.7 ± 11.4 | 0.265 |
| CTLA-4 on CD8+ | 27.7 ± 11.4 | 22.8 ± 12.9 | 0.056 |
| TIM3 in monocytes | 44.0 ± 19.7 | 31.8 ± 23.1 | 0.023 |
| PD-1 on monocytes | 16.3 ± 8.7 | 16.5 ± 10.7 | 0.952 |
| CLTA-4 on monocytes | 6.6 ± 4.8 | 5.6 ± 5.6 | 0.448 |
| CD14+ on monocytes | 53.9 ± 21.0 | 39.3 ± 23.3 | 0.008 |
| PD-L1 on CD14+ cells | 8.4 ± 14.6 | 8.2 ± 17.4 | 0.809 |
| PD-L2 on CD14+ cells | 45.6 ± 21.9 | 31.7 ± 22.3 | 0.025 |
| Galectin-9 on CD14+ cells | 12.3 ± 17.8 | 9.3 ± 16.8 | 0.519 |
Abbreviations: CTLA-4, cytotoxic T-lymphocyte-associated protein 4; LTBI, latent tuberculosis infection; PD-1, programmed death-1, TIM3, T cell immunoglobulin mucin domain-containing-3. Data are presented as mean ± standard deviation.